Studii clinice care sustin eficacitatea Viril-X

TRIBULUS TERESTRIS EXTRACT STANDARDIZAT

1: Singh SP, Raghavendra K, Singh RK, Mohanty SS, Dash AP. Evaluation of Tribulus terrestris Linn (Zygophyllaceae) acetone extract for larvicidal and repellence activity against mosquito vectors. J Commun Dis. 2008 Dec;40(4):255-61. PubMed PMID: 19579717.

2: Ivanova A, Serly J, Dinchev D, Ocsovszki I, Kostova I, Molnar J. Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators. In Vivo. 2009 Jul-Aug;23(4):545-50. PubMed PMID: 19567388.

3: Xu T, Xu Y, Liu Y, Xie S, Si Y, Xu D. Two new furostanol saponins from Tribulus terrestris L. Fitoterapia. 2009 Sep;80(6):354-7. Epub 2009 May 11. PubMed PMID: 19442708.

4: Wang SS, Ji YS, Li H, Yang SJ. [Mechanisms of gross saponins of Tribulus terrestris via activating PKCepsilon against myocardial apoptosis induced by oxidative stress]. Yao Xue Xue Bao. 2009 Feb;44(2):134-9. Chinese. PubMed PMID: 19408681.

5: Berkman Z, Tanriover G, Acar G, Sati L, Altug T, Demir R. Changes in the brain cortex of rabbits on a cholesterol-rich diet following supplementation with a herbal extract of Tribulus terrestris. Histol Histopathol. 2009 Jun;24(6):683-92. PubMed PMID: 19337967.

6: Altug Tuncer M, Yaymaci B, Sati L, Cayli S, Acar G, Altug T, Demir R. Influence of Tribulus terrestris extract on lipid profile and endothelial structure in developing atherosclerotic lesions in the aorta of rabbits on a high-cholesterol diet. Acta Histochem. 2009 Mar 6. [Epub ahead of print] PubMed PMID: 19269683.

7: Su L, Feng SG, Qiao L, Zhou YZ, Yang RP, Pei YH. Two new steroidal saponins from Tribulus terrestris. J Asian Nat Prod Res. 2009;11(1):38-43. PubMed PMID: 19177235.

8: Sengul M, Yildiz H, Gungor N, Cetin B, Eser Z, Ercisli S. Total phenolic content, antioxidant and antimicrobial activities of some medicinal plants. Pak J Pharm Sci. 2009 Jan;22(1):102-6. PubMed PMID: 19168430.

9: Su L, Chen G, Feng SG, Wang W, Li ZF, Chen H, Liu YX, Pei YH. Steroidal saponins from Tribulus terrestris. Steroids. 2009 Apr-May;74(4-5):399-403. Epub 2008 Dec 30. PubMed PMID: 19152803.

10: Swedell L, Hailemeskel G, Schreier A. Composition and seasonality of diet in wild Hamadryas baboons: preliminary findings from Filoha. Folia Primatol (Basel). 2008;79(6):476-90. Epub 2008 Oct 17. PubMed PMID: 18931503.

11: Dell'Agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7. Epub 2008 Sep 9. PubMed PMID: 18778098.

12: Lv AL, Zhang N, Sun MG, Huang YF, Sun Y, Ma HY, Hua HM, Pei YH. One new cinnamic imide dervative from the fruits of Tribulus terrestris. Nat Prod Res. 2008;22(11):1013-6. PubMed PMID: 18629718.

13: Kieley S, Dwivedi R, Monga M. Ayurvedic medicine and renal calculi. J Endourol. 2008 Aug;22(8):1613-6. PubMed PMID: 18620498.

14: Han M, Yang LM, Han DY, Yang L. [Study on fitting growth density and best harvest time of Tribulus terrestris]. Zhongguo Zhong Yao Za Zhi. 2008 Apr;33(7):750-3. Chinese. PubMed PMID: 18589769.

15: Wang H, Liu JR, Li P, Cheng YH. [A pharmacognostical study on Nitraria tangutorum]. Zhong Yao Cai. 2008 Jan;31(1):28-9. Chinese. PubMed PMID: 18589744.

16: Xu TH, Xu YJ, Xie SX, Zhao HF, Han D, Li Y, Niu JZ, Xu DM. Two new furostanol saponins from Tribulus terrestris L. J Asian Nat Prod Res. 2008 May-Jun;10(5-6):419-23. PubMed PMID: 18464080.

17: Saudan C, Baume N, Emery C, Strahm E, Saugy M. Short term impact of Tribulus terrestris intake on doping control analysis of endogenous steroids. Forensic Sci Int. 2008 Jun 10;178(1):e7-10. Epub 2008 Feb 20. PubMed PMID: 18282674.

18: Al-Bayati FA, Al-Mola HF. Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq. J Zhejiang Univ Sci B. 2008 Feb;9(2):154-9. PubMed PMID: 18257138; PubMed Central PMCID: PMC2225498.

19: Shinde VM, Dhalwal K, Mahadik KR, Joshi KS, Patwardhan BK. RAPD Analysis for Determination of Components in Herbal Medicine. Evid Based Complement Alternat Med. 2007 Sep;4(Suppl 1):21-3. PubMed PMID: 18227927; PubMed Central PMCID: PMC2206231.

20: Liu XM, Huang QF, Zhang YL, Lou JL, Liu HS, Zheng H. [Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats]. Zhong Xi Yi Jie He Xue Bao. 2008 Jan;6(1):45-50. Chinese. PubMed PMID: 18184546.

EPIMEDIUM SAGITATTUM EXTRACT STANDARDIZAT

1: Yan S, Wu B, Lin Z, Jin H, Huang J, Yang Y, Zhang X, Shen Z, Zhang W. Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium. Mol Biosyst. 2009 Oct;5(10):1204-13. Epub 2009 Jul 14. PubMed PMID: 19756310.

2: Chen CY. Computational screening and design of traditional Chinese medicine (TCM) to block phosphodiesterase-5. J Mol Graph Model. 2009 Aug 8. [Epub ahead of print] PubMed PMID: 19747866.

3: Hsieh TP, Sheu SY, Sun JS, Chen MH, Liu MH. Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression. Phytomedicine. 2009 Sep 9. [Epub ahead of print] PubMed PMID: 19747809.

4: Yao R, Zhang L, Li X, Li L. Effects of Epimedium flavonoids on proliferation and differentiation of neural stem cells in vitro. Neurol Res. 2009 Aug 21. [Epub ahead of print] PubMed PMID: 19703337.

5: Shen ZY, Huang JH, Lin W. [Transition of studying on Shen deficiency syndrome and aging from holistic concept to systematic biologic viewpoint]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Jun;29(6):548-50. Chinese. PubMed PMID: 19702091.

6: Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung UI, Nagamune T. Icariin: A Potential Osteoinductive Compound for Bone Tissue Engineering. Tissue Eng Part A. 2009 Aug 21. [Epub ahead of print] PubMed PMID: 19698057.

7: Zhang G, Wang XL, Sheng H, Xie XH, He YX, Yao XS, Li ZR, Lee KM, He W, Leung KS, Qin L. Constitutional flavonoids derived from Epimedium dose-dependently reduce incidence of steroid-associated osteonecrosis not via direct action by themselves on potential cellular targets. PLoS One. 2009 Jul 29;4(7):e6419. PubMed PMID: 19641620; PubMed Central PMCID: PMC2713419.

8: Wang C, Cao J, Liang Y, Huang W, Guo B. [Sampling in quality control of medicinal materials-A case of Epimedium]. Zhongguo Zhong Yao Za Zhi. 2009 Apr;34(8):1011-4. Chinese. PubMed PMID: 19639790.

9: Pan Y, Wang FM, Qiang LQ, Zhang DM, Kong LD. Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Psychoneuroendocrinology. 2009 Jul 23. [Epub ahead of print] PubMed PMID: 19631474.

10: Zhao L, Liu S, Luo J. [Separation and purification of total flavones from Herba Epimedii by macroporous adsorption resin with the help of ultrasonic extraction]. Zhongguo Zhong Yao Za Zhi. 2009 Mar;34(6):702-4. Chinese. PubMed PMID: 19624008.

11: Chen CY, Chang YH, Bau DT, Huang HJ, Tsai FJ, Tsai CH, Chen CY. Discovery of potent inhibitors for phosphodiesterase 5 by virtual screening and pharmacophore analysis. Acta Pharmacol Sin. 2009 Aug;30(8):1186-94. Epub 2009 Jul 13. PubMed PMID: 19597523.

12: Shen ZY, Huang JH, Wu B. [Activating effect and mechanism of epimedium on endogenous stem cells]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Mar;29(3):251-4. Chinese. PubMed PMID: 19548445.

13: Jiang F, Wang XL, Wang NL, Yao XS. Two new flavonol glycosides from Epimedium koreanum Nakai. J Asian Nat Prod Res. 2009;11(5):401-9. PubMed PMID: 19504382.

14: Songlin P, Ge Z, Yixin H, Xinluan W, Pingchung L, Kwoksui L, Ling Q. Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. Bone. 2009 Sep;45(3):534-44. Epub 2009 Jun 6. PubMed PMID: 19501202.

15: Qinna N, Taha H, Matalka KZ, Badwan AA. A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals. Int J Impot Res. 2009 Sep-Oct;21(5):315-20. Epub 2009 Jun 4. PubMed PMID: 19494825.

16: Li HB, Chen F. Separation and purification of epimedin A, B, C, and icariin from the medicinal herb Epimedium brevicornum maxim by dual-mode HSCCC. J Chromatogr Sci. 2009 May-Jun;47(5):337-40. PubMed PMID: 19476698.

17: Wong SP, Shen P, Lee L, Li J, Yong EL. Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract. J Pharm Biomed Anal. 2009 Sep 8;50(2):216-23. Epub 2009 May 3. PubMed PMID: 19464838.

18: Chen BL, Xie DH, Wang ZW, Li FB, Xu DL, Li YQ. [Effect of total flavone of epimedium on expression of bone OPG, OPGL mRNA in ovariectomized rats]. Zhongguo Gu Shang. 2009 Apr;22(4):271-3. Chinese. PubMed PMID: 19408755.

19: Li J, Lee L, Gong Y, Shen P, Wong SP, Wise SD, Yong EL. Bioassays for estrogenic activity: development and validation of estrogen receptor (ERalpha/ERbeta) and breast cancer proliferation bioassays to measure serum estrogenic activity in clinical studies. Assay Drug Dev Technol. 2009 Feb;7(1):80-9. PubMed PMID: 19382890.

20: Lee KS, Lee HJ, Ahn KS, Kim SH, Nam D, Kim DK, Choi DY, Ahn KS, Lu J, Kim SH. Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. Cancer Lett. 2009 Jul 18;280(1):93-100. Epub 2009 Mar 16. PubMed PMID: 19289254.

LEPIDIUM MEYENII EXTRACT STANDARDIZAT (MACA)

1: Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska L. Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause. 2008 Nov-Dec;15(6):1157-62. PubMed PMID: 18784609.

2: Baur H, Muller FJ, Gibson GA, Mason PG, Kuhlmann U. A review of the species of Mesopolobus (Chalcidoidea: Pteromalidae) associated with Ceutorhynchus (Coleoptera: Curculionidae) host-species of European origin. Bull Entomol Res. 2007 Aug;97(4):387-97. PubMed PMID: 17645820.

3: Lentz A, Gravitt K, Carson CC, Marson L. Acute and chronic dosing of Lepidium meyenii (Maca) on male rat sexual behavior. J Sex Med. 2007 Mar;4(2):332-9; discussion 339-40. PubMed PMID: 17367428.

4: Rubio J, Riqueros MI, Gasco M, Yucra S, Miranda S, Gonzales GF. Lepidium meyenii (Maca) reversed the lead acetate induced -- damage on reproductive function in male rats. Food Chem Toxicol. 2006 Jul;44(7):1114-22. Epub 2006 Feb 28. PubMed PMID: 16510228.

5: Ruiz-Luna AC, Salazar S, Aspajo NJ, Rubio J, Gasco M, Gonzales GF. Lepidium meyenii (Maca) increases litter size in normal adult female mice. Reprod Biol Endocrinol. 2005 May 3;3:16. PubMed PMID: 15869705; PubMed Central PMCID: PMC1131923.

6: Oshima M, Gu Y, Tsukada S. Effects of Lepidium meyenii Walp and Jatropha macrantha on blood levels of estradiol-17 beta, progesterone, testosterone and the rate of embryo implantation in mice. J Vet Med Sci. 2003 Oct;65(10):1145-6. PubMed PMID: 14600359.

7: Cicero AF, Piacente S, Plaza A, Sala E, Arletti R, Pizza C. Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts. Andrologia. 2002 Jun;34(3):177-9. PubMed PMID: 12059814.

8: Cicero AF, Bandieri E, Arletti R. Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity. J Ethnopharmacol. 2001 May;75(2-3):225-9. PubMed PMID: 11297856.

9: Zheng BL, He K, Kim CH, Rogers L, Shao Y, Huang ZY, Lu Y, Yan SJ, Qien LC, Zheng QY. Effect of a lipidic extract from lepidium meyenii on sexual behavior in mice and rats. Urology. 2000 Apr;55(4):598-602. PubMed PMID: 10736519.

PANAX GINSENG EXTRACT STANDARDIZAT

1: Baillard C, Bianchi A, Gehan G, Sitbon P, Denantes C, Benhamou D, Cupa M, Samama CM. [Anaesthetic preoperative assessment of chronic medications and herbal medicine use: a multicenter survey]. Ann Fr Anesth Reanim. 2007 Feb;26(2):132-5. Epub 2006 Dec 12. French. PubMed PMID: 17169523.

2: Furukawa T, Bai CX, Kaihara A, Ozaki E, Kawano T, Nakaya Y, Awais M, Sato M, Umezawa Y, Kurokawa J. Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. Mol Pharmacol. 2006 Dec;70(6):1916-24. Epub 2006 Sep 19. PubMed PMID: 16985185.

3: Vuksan V, Sung MK, Sievenpiper JL, Stavro PM, Jenkins AL, Di Buono M, Lee KS, Leiter LA, Nam KY, Arnason JT, Choi M, Naeem A. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis. 2008 Jan;18(1):46-56. Epub 2006 Jul 24. PubMed PMID: 16860976.

4: Sievenpiper JL, Sung MK, Di Buono M, Seung-Lee K, Nam KY, Arnason JT, Leiter LA, Vuksan V. Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation- and dose-finding studies. J Am Coll Nutr. 2006 Apr;25(2):100-7. PubMed PMID: 16582025.

5: Radad K, Gille G, Liu L, Rausch WD. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci. 2006 Mar;100(3):175-86. Epub 2006 Mar 4. Review. PubMed PMID: 16518078.

6: Nachtigal MC, Patterson RE, Stratton KL, Adams LA, Shattuck AL, White E. Dietary supplements and weight control in a middle-age population. J Altern Complement Med. 2005 Oct;11(5):909-15. PubMed PMID: 16296926.

7: Kelly JP, Kaufman DW, Kelley K, Rosenberg L, Anderson TE, Mitchell AA. Recent trends in use of herbal and other natural products. Arch Intern Med. 2005 Feb 14;165(3):281-6. PubMed PMID: 15710790.

8: Rowland DL, Tai W. A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions. J Sex Marital Ther. 2003 May-Jun;29(3):185-205. Review. PubMed PMID: 12851124.

9: Tsai SC, Chiao YC, Lu CC, Wang PS. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Chin J Physiol. 2003 Mar 31;46(1):1-7. PubMed PMID: 12817698.

10: Yoon HJ, Cho YH, Park J, Lee CH, Park SK, Cho YJ, Han KW, Lee JO, Lee CW. Assessment of estimated daily intakes of benzoates for average and high consumers in Korea. Food Addit Contam. 2003 Feb;20(2):127-35. PubMed PMID: 12623660.

11: Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Cui Y, Ang CY. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther. 2002 Sep;72(3):276-87. PubMed PMID: 12235448.

12: Murphy LL, Lee TJ. Ginseng, sex behavior, and nitric oxide. Ann N Y Acad Sci. 2002 May;962:372-7. Review. PubMed PMID: 12076988.

13: Kumar V, Singh PN, Bhattacharya SK. Anti-stress activity of Indian Hypericum perforatum L. Indian J Exp Biol. 2001 Apr;39(4):344-9. PubMed PMID: 11491579.

14: Qiu RX, Jin MH, Wu GZ. [Diphasic regulatory effect of lishen injection on sex hormones in senile female patients with coronary heart disease of kidney deficiency type]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 May;16(5):267-9. Chinese. PubMed PMID: 9387715.

15: Yun TK, Choi SY. A case-control study of ginseng intake and cancer. Int J Epidemiol. 1990 Dec;19(4):871-6. PubMed PMID: 2084014.

16: Tran Ty Yen. Stimulation of sexual performance in male rats with the root extract of dinh lang (Policias fruticosum L.). Acta Physiol Hung. 1990;75(1):61-7. PubMed PMID: 2339608.

17: Banerjee U, Izquierdo JA. Antistress and antifatigue properties of Panax ginseng: comparison with piracetam. Acta Physiol Lat Am. 1982;32(4):277-85. PubMed PMID: 6892267.

18: Kim C, Choi H, Kim CC, Kim JK, Kim MS. Influence of ginseng on mating behavior of male rats. Am J Chin Med (Gard City N Y). 1976 Summer;4(2):163-8. PubMed PMID: 937239.

19: KITAGAWA H, IWAKI R. [PHARMACOLOGICAL STUDY ON PANAX GINSEG.]. Nippon Yakurigaku Zasshi. 1963 Sep 20;59:348-54. Japanese. PubMed PMID: 14092710.